The bacterial pathogen Staphylococcus aureus controls many aspects of virulence by using the accessory gene regulator (agr) quorum sensing (QS) system. The agr system is activated by a macrocyclic peptide signal known as an autoinducing peptide (AIP). We sought to develop structurally simplified mimetics of AIPs for use as chemical tools to study QS in S. aureus. These quorum sensing inhibitors (QSIs) can competitively inhibit QS signaling system, providing an opportunity to develop new drugs against these targets to combat pathogens. This review focuses primarily on natural and synthetic QSIs targeting different components of the QS and their potential applications in medical fields. Fingerprint Dive into the research topics of 'Quorum sensing inhibitors of staphylococcus aureus from Italian medicinal plants'. Together they form a unique fingerprint. Hemolysin Proteins Medicine & Life Sciences Medicine & Life Sciences Staphylococcus aureus represents an opportunistic pathogen, which utilizes elaborate quorum sensing mechanisms to precisely control the expression and secretion of virulence factors. Previous studies indicated a role of the ClpXP proteolytic system in controlling pathogenesis. Tal-Gan Y, Stacy DM, Foegen MK, Koenig DW, Blackwell HE (2013b) Highly potent inhibitors of quorum sensing in Staphylococcus aureus revealed through a systematic synthetic study of the group-III autoinducing peptide. J Am Chem Soc 135:7869–7882. Morbidity and mortality estimates due to methicillin-resistant Staphylococcus aureus (MRSA) infections continue to rise. Therapeutic options are limited by antibiotic resistance. Anti-pathogenic compounds, which inhibit quorum sensing (QS) pathways, may be a useful alternative to antibiotics. Staphylococcus aureus and Enterococcus faecalis employ cyclic peptide-mediated quorum sensing (QS) systems, termed agr and fsr respectively, to regulate the expression of a series of virulence genes. To identify quorum sensing inhibitors (QSIs) that target agr/fsr systems, an efficient screening system was established. Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing in Staphylococcus aureus. ACS Biomaterials Science & Engineering 2015, 1 (10) , 1039-1049. DOI: 10.1021/acsbiomaterials.5b00313. Of the quorum sensing systems in Gram positive pathogens being targeted for chemical inhibition, the agr operon of Staphylococcus aureus has received noteworthy attention , . This interest derives from its significant medical burden [9] , its known propensity for developing resistance to newly introduced antibiotics [10] , and the failure of all vaccines to date to prevent infection [11] . Anti-pathogenic compounds, which inhibit quorum sensing (QS) pathways, may be a useful alternative to antibiotics. Staphylococcal QS is encoded by the AGR locus and is responsible for the
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